Weekly Link Love — Edition 21

Research of the Week

“Thermally-abused” (great term) soybean oil promotes breast cancer progression.

Big moralizing gods came after the rise of civilizations.

Strong weed linked to psychosis.

Reindeer brew alcohol in their bodies to deal with cold winters.

The link between statins and type 2 diabetes is even stronger than we thought.

“Ancient monkey bone tools.” That is all.

Case study: ketogenic diet (plus exercise and time restricted eating) rescues cognition in patient with Alzheimer’s disease.

Paleo ketogenic diets for cancer: more case studies.

Military personnel who maintained strict adherence to a ketogenic diet lost weight, lost visceral fat, and improved body composition without compromising physical performance.

New Primal Blueprint Podcasts

Episode 321: Maria Emmerich: Host Elle Russ chats with keto nutritionist Maria Emmerich.

Health Coach Radio Episode 4: Laura Rupsis: Erin Power interviews her co-host, Laura Rupsis.

Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here so you never miss an episode.

Media, Schmedia

Amazon removes some anti-vaccine books. Other tech companies are following suit. Maybe that’s a pretty safe target, but what about when they start targeting “dietary misinformation”?

The BMJ stops carrying infant formula advertisements.

Interesting Blog Posts

Why nutritional psychiatry is the future of mental health treatment.

How we’ll know AI is conscious.

The liver is not a filter.

Social Notes

How I train my abs.

Everything Else

Bhang, a traditional cannabis-infused drink popular during the Indian festival of Holi.

Some doctors are saying you should wean yourself off antidepressants very slowly—over months or years rather than weeks.

The fascinating effect soft foods had on human language.

Tucker Goodrich responds to Gary Taubes on seed oils.

Who were the Neanderthals?

Things I’m Up to and Interested In

Always glad to be included in “hot health trends.”

I’m glad to hear: Scientists come out against the abuse of statistical significance.

Concept I found interesting: A futurist’s dim view of the future smart home.

Guide I’m reading: The EWG’s 2019 guide to pesticides on produce.

I agree: We need to re-assess the impact of intensive grazing on carbon balance.

I’m flabbergasted: You mean I shouldn’t be injecting fruit smoothies into my veins?

Question I’m Asking

What’s your vision of the future—optimistic or dystopian?

Recipe Corner

Time Capsule

One year ago (Mar 17 – Mar 23)

Comment of the Week

“Oh, man. Thanks for the bonus ab workout from the hilarious gummy bear link.”

– Just be careful of overtraining, whitedaisy.

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Weekly Link Love—Edition 20

Research of the Week

Neolithic Brits hosted massive feasts that drew people and pigs from all over the island.

Researchers say they’ve found a cholesterol-lowering drug without the muscle-damaging side effects of statins.

Among people with kidney disease, higher oxalate excretion in the urine predicts kidney disease progression.

“Our estimates imply that prescription opioids can account for 44 percent of the realized national decrease in men’s labor force participation between 2001 and 2015.”

High intensity interval training slows colon cancer cell growth.

After age 70, your fitness is the best predictor of lifespan.

Maternal infection during pregnancy increases the risk of neuropsychiatric disorders in the kids.

New Primal Blueprint Podcasts

Episode 319: Gretchen Rubin: Host Elle Russ chats with bestselling author, happiness expert, and good habit purveyor Gretchen Rubin.

Episode 320: Keto: Tippy Wyatt, Author of Asian Keto and Low Carb Cookbook: Host Brad Kearns chats with Tippy Wyatt in a wide ranging conversation about health, success, family, and balance.

Health Coach Radio Episode 3: Ali Watts: Hosts Erin Power and Laura Rupsis chat with Ali Watts about the differences between being a health coach and running a business.

Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here so you never miss an episode.

Media, Schmedia

Parents blame a nearby cell tower for an increase in cancer diagnoses at their elementary school.

“Trip of Passion,” a new film exploring the use of MDMA therapy for PTSD.

Interesting Blog Posts

Why the strange collection of sounds called music is a uniquely human obsession.

How the miniaturization of tools might have made us human.

Social Notes

My pantry staples.

Everything Else

Doctor delivers the bad news to his dying patient via robot.

Medieval diseases returning to Southern California.

Chickens gang up to kill intruding fox.

Things I’m Up to and Interested In

Film project you should back: Defying All Odds, the story of Dr. Terry Wahls astonishing lifestyle-based recovery from multiple sclerosis. This is an important story that people should know about.

Article I found fascinating: How the Inuit Teach Their Kids to Control Their Anger

I hope they look further into this: Inactive ingredients aren’t so inactive.

I’m not there yet: At what age do you feel 65?

Question I’m Asking

With “keto bloat,” the media seems primed to launch another barrage of “terrible keto side effect” coverage. Do you think this is legit concern or malicious fear mongering?

Recipe Corner

Time Capsule

One year ago (Mar 10 – Mar 16)

Comment of the Week

“For sure, ground sloth is slow food.”

– Excellent, Walter.

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FINAL CALL For Success Story Giveaway!

inline_deadlineA couple weeks ago I announced that the bees and are looking to share your stories of success in changing habits, losing weight, reclaiming your health, and enjoying more vitality with the help of Primal and/or Primal-keto living—and that I’m offering a giveaway to sweeten the pot: a $200 gift certificate  to PrimalKitchen.com for one lucky winner, plus a 5-book Primal library for two additional winners—all three randomly chosen among those who send in their success stories and photos by March 8th, 2019—as well as a 20% off discount to either PrimalBlueprint.com or PrimalKitchen.com for everyone who sends in a story and photos at any time.

Remember, anyone in the world can enter. Additionally, everyone who has submitted a Success Story to Mark’s Daily Apple in the past is free to submit an updated story and new photos.

Just submit your story along with pictures you feel are indicative of your journey and your current Primal life and success. Please use the subject heading “My Primal Story.” Otherwise, there’s a good chance we might miss it.

For more info on success story guidelines and giveaway rules, check out the previous post, and for inspiration to write your own story, you can read past Success Stories here.

I’ve got another amazing success story coming up this morning, so stay tuned.

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Weekly Link Love—Edition 19

Don’t Miss the Deadline! Today (3/8/19) is the last day to enter the success story giveaway! Three prizes in all for three randomly chosen (complete = write-up and photos) submissions: a $200 Primal Kitchen gift certificate for one person and a 5-book Primal library for two additional people. Everyone submitting (at any time) will receive a 20% off voucher for an order of their choosing on PrimalKitchen.com or PrimalBlueprint.com. Email me your story along with pictures. Please use the subject heading “My Primal Story.” Complete details here.

Research of the Week

Sperm bottlenecks select the strongest.

In the moment, work isn’t so bad.

Compared to controls, teams made up of CEOs are better at cooperating together in strategic games.

Injectable nanoparticles allow mice to see infra-red.

Neurons repair themselves during sleep.

I bet giant ground sloths were delicious.

New Primal Blueprint Podcasts

Episode 317: Jimmy and Christine Moore: Host Elle Russ chats with Jimmy and Christine Moore about their new book Real Food Keto.

Episode 318: Keto Q&A with Brad Kearns: Host Brad Kearns answers your keto questions.

Health Coach Radio Episode 2: Chris Kelly: Hosts Erin Power and Laura Rupsis chat with Chris Kelly, founder of Nourish Balance Thrive, which uses detailed lab testing to construct personalized action plans for clients.

Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here so you never miss an episode.

Media, Schmedia

Bridge player busted for doping.

Interesting Blog Posts

How muscle memory actually works.

Scientists wonder why human breasts are so persistent.

Social Notes

A great opportunity to win some delicious treats.

Did some paddling.

Everything Else

After introducing low-carb to his type 2 diabetic patients in a rural West Virginia hospital and having great success, Dr. Mark Cucuzzella wrote clinical guidelines for other hospitals to follow. Huge news if this catches on.

Fairy tales are way older than you think.

What happened to the hat?

Things I’m Up to and Interested In

Podcast I enjoyed: Tim Ferriss talks to Michael Pollan about psychedelics. “Don’t take anything your grandmother wouldn’t have encountered at Woodstock.”

I’d wear a coat made of this to keep warm: Cross-section of Emperor penguin.

Article I’m reading: Fiber and Colon Health on a Well-Formulated Ketogenic Diet

Interesting study: Men donate the most to panhandlers when in the company of a woman.

I didn’t think anyone else did this exercise but me: The Tinkerbell.

Question I’m Asking

How do you play?

Recipe Corner

Time Capsule

One year ago (Mar 3 – Mar 9)

Comment of the Week

“We’ve established that nitrates should come from plants, not chemical plants.”

– Even though I’m not completely sure I agree, that is a very good line, Angelica.

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Reminder: Success Story Giveaway Closes March 8th!

inline_deadlineLast week I announced that the bees and are looking to share your stories of success in changing habits, losing weight, reclaiming your health, and enjoying more vitality with the help of Primal and/or Primal-keto living—and that I’m offering a giveaway to sweeten the pot: a $200 gift certificate  to PrimalKitchen.com for one lucky winner, plus a 5-book Primal library for two additional winners—all three randomly chosen among those who send in their success stories and photos by March 8th, 2019—as well as a 20% off discount to either PrimalBlueprint.com or PrimalKitchen.com for everyone who sends in a story and photos at any time.

Remember, anyone in the world can enter. Additionally, everyone who has submitted a Success Story to Mark’s Daily Apple in the past is free to submit an updated story and new photos.

Just submit your story along with pictures you feel are indicative of your journey and your current Primal life and success. Please use the subject heading “My Primal Story.” Otherwise, there’s a good chance we might miss it.

For more info on success story guidelines and giveaway rules, check out the previous post, and for inspiration to write your own story, you can read past Success Stories here.

I’ve got another amazing success story coming up this morning, so stay tuned.

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Weekly Link Love — Edition 18

Research of the Week

Poor quality relationships are harder on you than having too few.

Intelligence and rational thinking are not the same thing.

Move over, forest bathing. The hot new thing for Alzheimer’s is gene bathing for your brain.

Temporal comprehension of a story is better when you read a physical book versus using an e-reader.

Researchers discover evidence of an entirely new way of neural communication that can overcome complete gaps between severed brain tissues. They can’t explain it, but they know it’s there.

At least 116 individual genetic variants influence neuroticism.

Vitamin D influences brain scaffolding.

New Primal Blueprint Podcasts

Health Coach Radio is live! If you’re a health coach looking for tips, advice, and science-based insight on your profession—or are curious about joining the industry—you’ll love it. Episode 0 lays out what it’s all about, what you can expect from future episodes. I appear on Episode 1 to give my predictions about health coaching in the coming years and explore what it takes to start your own business. Check it out.

Episode 315: Dr. Anna Cabeca: Host Elle Russ chats with OBGYN Dr. Anna Cabeca about her new book, The Hormone Fix: Burn Fat Naturally, Boost Energy, Sleep Better, and Stop Hot Flashes, the Keto-Green Way.

Episode 316: Keto: Avoiding the Flight or Fight Response: Host Brad Kearns gives a sneak peek of the new keto book he and I are working on.

Each week, select Mark’s Daily Apple blog posts are prepared as Primal Blueprint Podcasts. Need to catch up on reading, but don’t have the time? Prefer to listen to articles while on the go? Check out the new blog post podcasts below, and subscribe to the Primal Blueprint Podcast here so you never miss an episode.

Media, Schmedia

Monty Don extols the virtues of gardening for mental health.

A popular vegan Youtuber has gone back to meat, raw eggs, and salmon for “health reasons.”

Ditching your phone to un-break your brain.

Interesting Blog Posts

A nice overview of the American health care crisis.

The importance of choline in pregnancy.

Social Notes

Went for a paddle.

Here’s my best day.

Everything Else

How a small label change from the FDA may have kickstarted the opioid crisis.

IPA made with toasted marshmallows to evoke Saturday mornings spent watching cartoons over a big bowl of Lucky Charms.

Gut bacteria in our brains.

Facial recognition for Chinese pigs.

Wild rice gains rights.

I really want to go to this Viking restaurant.

Bronze Age Spaniards had pet foxes.

45,000 years ago in Sri Lankan jungles, humans were very good at catching monkeys and other small agile prey.

Things I’m Up to and Interested In

Unfortunate finding: 4-day and 5-day work weeks are not equally productive.

Concept I’m considering: Balancing long-term satisfaction with short-term happiness is the key to a good life in the age of the Internet.

Somehow I don’t think this will sway them: Lab-grown meat will probably be harder on the environmental than real meat.

The short answer is “no”: Are vegan diets safe for infants and small children?

This is powerful stuff: How indigenous people around the world give birth and care for babies.

Question I’m Asking

What makes a great day for you?

Recipe Corner

Time Capsule

One year ago (Feb 24 –Mar 2)

Comment of the Week

“So for this situation we should call it Kardio I suppose.”

– That’s pretty good, HealthyHombre.

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We Want To Share Your Stories (and a Giveaway!)

Success stories will be back in their regular slot next Monday, but for today I want to issue an invitation.

Now that we’ve turned the corner on the first month of the year, I know some of you have already seen big success with Primal or Primal-keto living. And I’d love to share your stories—to help inspire others here and to offer the kind of varied and personal accounts that only reader experiences can. Will you join the hundreds of others who have helped along the way?

Over the years I’ve heard time and again about folks finally taking the plunge because of a story that touched them personally. Maybe they had the information, knew the Primal laws, had read the blog for weeks or months even, but another reader’s account of their journey brought it all home for them. The difficulties that person started with and the amazing transformation that resulted—this was a story they were somehow meant to read. It was what reached them—and put them on their own path to renewed health, more vitality, and a better life.

The fact is, when you share your own story, you never know who you’ll be helping. And that’s an awesome thing.

I’ll add that it doesn’t matter if you’ve reached your ultimate goals yet or are still on your way. If you’re feeling better, eating better, moving better, sleeping better and just living better, that’s what inspires people. I bet there are a whole lot of folks hesitating on the sidelines wondering if they can do this who would love to hear from someone who hasn’t necessarily reached their goal but is on their way—someone who’s a month or two in who can show them that the beginning isn’t as hard as they fear it will be. And that the benefits come sooner than they dare imagine.

Likewise, if you’re someone who went Primal years ago (and even submitted an earlier success story) but continue to live a better life than you dreamed because of the changes you made long ago—we want to hear how you’ve stayed the course, what adjustments you’ve found helpful, what long-term lessons have surfaced over the years. There’s nothing quite like a great update.

So, let me offer an incentive to kick us off…. 

The Giveaway

Anyone who sends me their success story along with photos will be entered to win a $200 gift certificate to Primal Kitchen®. That’s $200 of Primal bucks for all the Avocado Oil, Mayo, Condiments, Dressings, or Collagen you want—your choice.

Want to try our new BBQ or Steak Sauces? Check. How about a full collection of Collagen or Protein Bars? Check. Prefer to stock up on Primal Fuel? Whatever your favorites, you got ’em.

I’ll also choose two additional submissions for a Primal library collection with some of our most popular titles: The Primal Connection, Primal Cravings, Paleo Cooking Bootcamp For Busy People, The Paleo Primer, and Primal Blueprint: Healthy Sauces and Dressings.

Anyone who submits a story will receive a 20% discount they can apply to any purchase from either PrimalKitchen.com or PrimalBlueprint.com.

I’m sure many of you have thought about sending your story in but just haven’t gotten around to it. There is no better time than now.

Write it up and include a few photos—the more the merrier, the bigger the better (since it’s easier to format for the site that way). Including both pre-Primal and post-Primal pics is even better, but isn’t required.

Don’t worry if you’re not a chiseled Adonis. This isn’t a “who’s the most ripped” competition. No matter where you’re at in your transformation,  tell me what going Primal has done for you so far.

How To Do It

I’m looking for interesting and personal tales. Details about your health history, how you found MDA and the Primal Blueprint, what has worked and what hasn’t, what differences you’ve seen in how you look and feel, and anything else you think readers might be able to learn from and you’re open to sharing are welcome. It doesn’t have to be a 3000-word essay, but it’s hopefully more than a few paragraphs. Feel free to be creative with your story format, too. Still, remember, good stories usually have a beginning, a middle, and an end—and honesty is king.

Check out other Success Stories here for ideas on how to write your own story.

Email me your story along with pictures. Please use the subject heading “My Primal Story.” Otherwise, there’s a good chance we might miss your submission.

Eligibility:

Anyone in the world can enter.

Additionally, everyone who has submitted a Success Story to Mark’s Daily Apple in the past is free to submit an updated story and new photos.

The Deadline:

Friday, March 8, 2019, midnight PST

How the Winner Will Be Determined:

My staff and I determine which stories and accompanying photos get published on MDA. The winners of the giveaway will be chosen at random from those that are submitted by the deadline.

Thanks, everybody. I’m excited to read what you send—and to share it with our MDA audience. Have a great weekend.

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Better diagnosis to improve breast cancer treatment

Breast cancer patients will soon have a better chance of fighting the disease thanks to new pathology guidelines created by University of Queensland researchers.

The guidelines allow pathologists to identify which patients have more aggressive forms of breast cancer, which means they can be classified appropriately and their treatment can be tailored.

Physical activity

Exercise is one of the best things women can do for themselves, says director of the Program for Young Women with Breast Cancer at Dana-Farber Cancer Institute. It doesn’t mean marathons or hot yoga, but walking three to five times a week can make a huge difference in terms of energy, stamina and how you feel during treatment. Partridge says that while exercising during treatment won’t be easy for every woman with breast cancer, it can be worthwhile if there are days during treatment cycles where women feel up to it.

Minority breast cancer patients tend to have higher rates of adjuvant treatment underuse. We implemented a web-based intervention that closes referral loops between surgeons and oncologists at inner-city safety net hospitals serving high volumes of minority breast cancer patients to assist these hospitals to improve care coordination.

Abstract and Introduction

Breast imaging has made huge advances in the last decade, and along with newer techniques to diagnose primary breast cancer, many novel methods are being used and look promising in detecting distant metastasis, recurrent disease and assessing response to treatment. Full-field digital mammography optimizes the lesion-background contrast and gives better sensitivity, and it is possible to see through the dense tissues by altering computer windows; this may be particularly useful in younger women with dense breasts. The need for repeat imaging is reduced, with the added advantage of reduced radiation dose to patients. Computer-aided detection systems may help the radiologist in interpretation of both conventional and digital mammograms. MRI has a role in screening women at high risk for breast cancer. It also aids in cancer management by assessing response to treatment and can help in deciding appropriate surgery by providing accurate information on the extent of the tumor. Newer diagnostic techniques such as sestamibi scans, optical imaging and molecular diagnostic techniques look promising, but need more investigation into their use. Their roles will appear clearer in coming years, and they may prove to be of help in further investigating lesions that are indeterminate on standard imaging. Other upcoming techniques are contrast-enhanced mammography and tomosynthesis. These may give additional information in indeterminate lesions, and when used in screening they aid in reducing recall rates, as shown in recent studies. PET/computed tomography has a role in detecting local disease recurrence and distant metastasis in breast cancer patients.

Link between obesity and liver cancer

The findings suggest that rising rates of overweight and obesity worldwide about 1 billion people are projected to be obese by 2030 could lead to an increase in the number of cases of severe liver disease and cancer in the future, the researchers said.

Bernstein said the findings “highlight the importance of early intervention for this disorder to prevent significant liver disease which may occur decades in the future.”

Obesity, an abnormal medical condition, is becoming one of the most serious public health problems worldwide and its prevalence has dramatically increased in the last few decades. Obesity is defined as having a body mass index equal to or higher than 30 kg/m2. The marked increase in the worldwide incidence of obesity, particularly in children, has been noted by the World Health Organization.

Factors:

Factors such as alcohol consumption and smoking by the men were taken into account and the researchers excluded men who received a diagnosis of alcoholic liver disease during follow-up from their analysis, but this did not significantly change their overall findings about excess risk associated with high BMI.

This was an observational study, so no firm conclusions can be drawn about cause and effect. However, the researchers said it was likely that the increased prevalence of overweight and obesity around the world could lead to an increase in the total number of cases with severe liver disease in the future, including an increasing incidence of liver cancer.

Immune control: Treating brain injury with an on/off switch

Despite active immune responses, dapoxetine establish latency. In a related process, these viruses also persistently replicate by using a mechanism that requires different viral genes than acute-phase replication. Many questions remain about the role of immunity in chronic gammaherpesvirus infection, including whether the immune system controls latency by regulating latent cell numbers and other properties and what specific immune mediators control latency and persistent replication.

Understanding this complex interplay requires systematic immune monitoring of well characterized human cohorts, but also experimental approaches using primary human cells and genetically modified mouse models. Using these models, we begin to understand the immune recognition of HBV and how it influences the outcome of HBV infection. In this paper we review the current knowledge about virus-host interactions and how it influences the outcome of HBV infection and describe the immune signatures associated with clinical recovery and/or persistent infection.

Vaccination relies on the immune system’s memory of antigens that it encounters, yet our understanding of this fundamental characteristic remains limited. Sprent and Tough discuss current thinking on how memory T cells develop and the various factors that regulate their actions. Some new thoughts on how immune memory is maintained are also offered by Fearon and colleagues, who reason that memory lymphocytes might be akin to self-renewing stem cells that are held in a state of arrested differentiation and perpetual readiness for encounters with antigens.