Link between obesity and liver cancer

The findings suggest that rising rates of overweight and obesity worldwide about 1 billion people are projected to be obese by 2030 could lead to an increase in the number of cases of severe liver disease and cancer in the future, the researchers said.

Bernstein said the findings “highlight the importance of early intervention for this disorder to prevent significant liver disease which may occur decades in the future.”

Obesity, an abnormal medical condition, is becoming one of the most serious public health problems worldwide and its prevalence has dramatically increased in the last few decades. Obesity is defined as having a body mass index equal to or higher than 30 kg/m2. The marked increase in the worldwide incidence of obesity, particularly in children, has been noted by the World Health Organization.

Factors:

Factors such as alcohol consumption and smoking by the men were taken into account and the researchers excluded men who received a diagnosis of alcoholic liver disease during follow-up from their analysis, but this did not significantly change their overall findings about excess risk associated with high BMI.

This was an observational study, so no firm conclusions can be drawn about cause and effect. However, the researchers said it was likely that the increased prevalence of overweight and obesity around the world could lead to an increase in the total number of cases with severe liver disease in the future, including an increasing incidence of liver cancer.

Can Viagra permanently damage vision?

Side effects can be even from the most innocuous pills, didn’t you know? But who would have thought that the beloved men “Viagra” can do harm instead of good.

What do you know about Viagra? The drug called sildenafil, it is “Viagra”, is used in the treatment of erectile dysfunction. In simple terms, it helps in problems with erection. Also, this drug can help in the treatment of gastroparesis and such a serious disease, as arterial hypertension. Not bad, if you do not take into account the fact that there may also be side effects, and quite serious ones.

Viagra: blindness instead of erection?

Science World Report recently revealed that researchers at the University of New South Wales have discovered that Sildenafil has a negative effect on human vision. The fact is that this drug hinders the normal functioning of the enzyme, which plays a decisive role in the transportation of light signals from the eye to the human brain. Particularly susceptible to people who have eye disease that can lead to blindness or with retinitis pigmentosa.

But also people with good eyesight are exposed to negative effects, because without knowing it, they can be carriers of the gene that causes retinitis pigmentosa. By the way, such a mutation can occur in 2% of the human population, that is, every 50th. Retinitis pigmentosa can develop due to mutations in the gene that produces the PDE6 enzyme. Patients who have two copies of an altered gene can get this disease. In simple terms, the man does not realize that he may have some problems with his eyesight, but if the entanglement of stars rewarded him with the wrong combination of genes, then taking Viagra, he can be awarded with visual illness.

The study conducted experiments on mice. Healthy and sick people were given a single dose of sildenafil for such a gene mutation. After it, even in healthy mice, there was a temporary loss of vision, not to mention mice with mutations. In the pupils of animals, scientists noticed signs of cell death. Thus, retinal disease carriers are affected by significant degeneration.

It is worth noting that before this study, scientists knew about temporary violations of the quality of vision in healthy people in the case of receiving high doses of their beloved Viagra. So, high sensitivity to bright light, as well as color disturbance, a kind of blurred vision is prescribed in such effects of this drug. Therefore, now scientists believe that the appointment of “Viagra” doctors should keep in mind that the consequences for the eye can be much more serious than temporary blurred vision. Another thing is that usually men take this drug without a prescription. So, it makes sense to think about the consequences of such “self-treatment”.

Immune control: Treating brain injury with an on/off switch

Despite active immune responses, dapoxetine establish latency. In a related process, these viruses also persistently replicate by using a mechanism that requires different viral genes than acute-phase replication. Many questions remain about the role of immunity in chronic gammaherpesvirus infection, including whether the immune system controls latency by regulating latent cell numbers and other properties and what specific immune mediators control latency and persistent replication.

Understanding this complex interplay requires systematic immune monitoring of well characterized human cohorts, but also experimental approaches using primary human cells and genetically modified mouse models. Using these models, we begin to understand the immune recognition of HBV and how it influences the outcome of HBV infection. In this paper we review the current knowledge about virus-host interactions and how it influences the outcome of HBV infection and describe the immune signatures associated with clinical recovery and/or persistent infection.

Vaccination relies on the immune system’s memory of antigens that it encounters, yet our understanding of this fundamental characteristic remains limited. Sprent and Tough discuss current thinking on how memory T cells develop and the various factors that regulate their actions. Some new thoughts on how immune memory is maintained are also offered by Fearon and colleagues, who reason that memory lymphocytes might be akin to self-renewing stem cells that are held in a state of arrested differentiation and perpetual readiness for encounters with antigens.

Newborn babies’ brain responses to being touched on the face measured for the first time

A newborn baby’s brain responds to being touched on the face, according to new research co-led by UCL. Babies use this sense of touch – facial somatosensation – to find and latch onto their mother’s nipple, and should have this ability from birth.

Premature babies often have difficulty feeding, and underdevelopment of their facial sensitivity may be one of the main causes. Researchers from UCL, Imperial College London, UCLH and Universitá Campus Bio-Medico di Roma developed a new method to study this sense of touch in babies and how their brains reacted using electroencephalography.

Current methods of evoking brain activity in response to touch aren’t suitable for a newborn’s face, so academics have developed a device – based on a transducer – worn on the fingertip, covered by a clinical glove. The baby can be lightly tapped on the cheek, and then brain responses are measured as well as the force of the tapping.

The report, “A novel sensor design for accurate measurement of facial somatosensation in pre-term infants”, is published in the journal PLOS ONE.

Climax

The new Climax Professor of Clinical Therapeutics will join the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the Medical Sciences Division and St Hilda’s College in February 2019 to lead Oxford’s answer to a key global challenge – how to determine quickly which potential new therapies have the properties to become important medicines.

Old penis – erectile dysfunction

Old penis is associated with many unpleasant things. Unfortunately, some of them are true. Probably, this list may help you to get ready for these changes. Also, you may think of how you can make things better. For example, there are quite a lot of possibilities to fight erectile dysfunction at any age.
Maybe, this evidence proving that genetic erectile dysfunction exists, will make you happy. According to the newest study, a certain part of the DNA might affect impotence in men. Good for you? Bad for you? Anyway, the news seem fantastic!

Irreversible reduction in size (most likely)

Not just cringing, like after swimming in a cool pool. This is an irreversible, progressive reduction in the size of the penis. Because normal cells, used to be strong and healthy, are replaced by inelastic tissues as you age.
In the course of twin studies conducted in 2004, scientists have established that ED and impotence may be associated with the genetics of the patient. In fact, the connection was noted in a third of cases.
Researchers at the University of California at San Francisco and the University of Washington Medical School collected a “risk group” that included 14 thousand men with a clinical diagnosis of erectile dysfunction. In addition, they were able to study the DNA of 222 thousand people from the UK Biobank.

About Erectile Dysfunction

What Is Erectile Dysfunction?

Erectile dysfunction has many possible causes and can be the first symptom of an undiagnosed condition. Erections are caused by the balance of blood flow into and out of the penis. Conditions that result in changes in the penis’ blood flow are common causes of ED. The 2 most common medical problems that may cause ED are atherosclerosis and diabetes. Obesity is also associated with both blood vessel changes and hormone changes that negatively affect erections. Another cause of ED is damage to the nerves involved in getting erections. This can happen with diseases of the nervous system (eg, multiple sclerosis, Parkinson disease) or with surgery (eg, for prostate cancer). Hormone problems, like low testosterone, and side effects of medications, like those used to treat high blood pressure, can also cause ED.

Erectile dysfunction, also referred to as impotence, is a problem getting or keeping an erection hard enough for satisfactory sexual performance. Erectile dysfunction is present in 1 of 2 men older than 40 years. Other types of male sexual dysfunction can include problems with libido (sexual interest), orgasm, or ejaculation.

Erectile dysfunction problem o NO?

You can take Viagra, Cialis or Levitra (there are many other pills, Kamagra, for example) and everything will be fine. The penis will be big! And not to ejaculate quickly – take dapoxetine

Treatments for Erectile Dysfunction

A wide range of treatment options are available and allow physicians to tailor treatment to a patient’s specific goals. Erectile dysfunction should always be evaluated by a medical professional. Many products available on the Internet or in stores claim to help ED but are not proven to be safe or effective. The first step in treating ED is often making lifestyle changes. Losing weight by dieting and exercising may be all that is needed to improve erections. You should also reduce alcohol intake and avoid smoking and illicit drug use. If ED is the result of a medication side effect, your physician may recommend alternative medications. Psychosocial therapy is effective when emotional or psychological factors contribute to ED. Medications are commonly used to treat ED. All ED medications work by increasing the blood flow to the penis. These pills are safe and effective when used under the supervision of a physician.

Erectile Dysfunction in Young Men

Introduction

Erectile dysfunction (ED) is an important health concern that can significantly affect a man’s psychosocial well-being. ED has traditionally been considered a disease of old age; however, contemporary evidence suggests a growing incidence of ED in men younger than 40 years. The process of achieving an erection is multifaceted; there are many potential mechanisms that can be disrupted. It is critical to identify the specific causes of ED before proceeding with potentially costly and invasive therapeutic options. Advances in diagnostic and treatment modalities offer opportunities to identify and manage young men with ED.

To provide an update on the prevalence and risk factors of ED in young men and to provide a framework to guide clinicians in identifying and managing the affected young man.
Methods

Comprehensive review of the literature pertaining to ED in young men.

ED in young men was assessed by outlining the prevalence according to recent epidemiologic studies. The pathophysiology, diagnostic considerations, risk factors, and etiologies were reviewed.
Results

Large multinational studies have estimated the prevalence of ED in young men to be as high as 30%. Several studies have stratified the etiologies of ED into psychogenic and organic causes. Psychogenic etiologies of ED include depression, anxiety, and partner-related difficulties. These patients tend to experience sudden onset of symptoms, with decreased libido and good quality of spontaneous or self-stimulated erections. Organic etiologies include vasculogenic, endocrinologic, neurogenic, iatrogenic, and structural components. These patients usually experience gradual onset of symptoms and a low to normal libido. Conservative treatments such as phosphodiesterase type 5 inhibitors continue to be the mainstay treatment.

Conclusions

ED in young men is an increasingly common condition. A careful diagnostic evaluation should focus on the identification of any underlying etiology to ensure appropriate management of patients.